Literature summary extracted from

Li, X.; Qian, X.; Lu, Z.
Fructokinase A acts as a protein kinase to promote nucleotide synthesis (2016), Cell Cycle, 15, 2689-2690.

Application

EC Number	Application	Comment	Organism
2.7.1.3	medicine	mutually exclusive splicing of adjacent exons 3A and 3C in ketohexokinase precursor RNA results in expression of ketohexokinase isoform KHK-A or KHK-C. KHK-A but not KHK-C interacts with phosphoribosyl diphosphate synthetase PRPS1. KHK-A functions as a protein kinase and directly phosphorylates PRPS1 at T225. This phosphorylation blocks the binding of the allosteric inhibitor ADP to PRPS1, thereby abrogating the feedback inhibition by ADP and leading to elevated de novo nucleic acid synthesis by constitutively activating PRPS1 in hepytocellular carcinoma cells	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.1.3	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.3	Homo sapiens	-	-	-

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Release 2023.1 (January 2023)